Have you heard of "sociogenomics," or of "polygenic scores" ?

We hadn't when we tripped over an article in the New York Times titled A new scientific field is recasting who we are and how we got that way by Dalton Conly of Princeton University. It highlights scientific progress in genetics by answering some questions such as: “how do our genes predetermine our health, or our success in life.” The article in questions is an interesting case study in wokeness as well, but we won’t go into that.

In this post, we’ll try (1) to recast the new scientific context, now dubbed sociogenomics, a fusion of behavioural science and genomics, and (2) list a few important results. Here we go:

Throughout human history, genetics (“blood”, or “family line” in ancient parlance), was held to determine the future of our offspring. Ch. Darwin and G. Mendel made important contributions (Darwin, in this blog’s opinion, was the pivotal killer of “faith-based” believe systems (religions)). Then, F. Crick and J. Watson decoded the workings of the DNA—explaining how “sex” works in creating inherited traits, and we got used to the idea that specific traits are connected to specific genes.

 

But then came the discovery that some traits are not linked to one gene, but correlated to a whole profile of genes, which led to the construction of so-called polygenetic indexes. Initially, research focused on the genetic profiles (PGI-scores) of specific diseases--63% of breast cancer incidence can now be linked to polygenetic factors, or 71% of schizophrenia. But then it became clear that all kinds of things human are related to all kinds of polygenetic factors.

Take educational attainment: among adults who score very low on the corresponding PGI, only 7% finish college. Among those whose score is very hight, the number is 71%.  PGI’s have been created for more than 3500 traits, from sleep habits to right- or left-handedness and extroversion.

But that’s not all. PGI’s codetermine social behaviour. Children who have genes that correlate to more success in school evoke more intellectual engagement from their parents than kids in the same family who don’t share these genes. This feedback loop starts at the age of 18 month, long before any assessment of academic ability. In other words, parents don’t just parent their children, children parent their parents, somehow---somewhat mysteriously---guided buy their genes. And it turns out that genetic guidance happens everywhere. People in the US tend to marry people with similar genetic profiles. Very similar, in fact: spouses are on average the genetic equivalents of their first cousins once removed. Even more mysteriously, there’s the effect of lateral gene transfer (something very popular among microbes): your spouse's genes influence your likelihood of depressions almost a third as much as your own genes do. The presence of a few genetically predisposed smokers in high school appears to cause smoking rates to spike for an entire grade---even among those students who didn’t personally know those nicotine-prone classmates---spreading like a genetically sparked wildfire through the social network.   

Polygenetic indexes have spread rapidly and are now arriving in IVF-clinics. In the past, one could already screen embryos for some genetic diseases, but soon you will be able to screen them for happiness and success in life. It’s a brave new world out there. Be prepared.

Talent borrows, genius steals

 

TESLA---the car company---was going through a rough spell...(market-wise, we mean)...but now Glenn, our friend, sends this...

...and the sun shines again on the Tesla stock price.

Hold on, didn't we promise a third installment of our new comedy, about Dolly, the new robot? And, yes, coincidences never happen (classical deterministic mechanics), and so we have a line about Elon Musk in this comedy. Here it is (Steve (founder of a planetary maker of robots), and Eliza (his former lover) in conversation):

ELIZA (TURNING TO STEVE:) ...Capitalism brought you here, Steve.

STEVE: Capitalism? The secret tube for billionaires brought me here, Elon Musk's vacuum tube under the Atlantic with magnetic levitation trains running at twelve times the speed of sound. I caught the last one.

ELIZA: The DEMISE of capitalism brought you here, I mean...but that's not all... 

...(sorry to interrupt)..."Demise of capitalism", you wonder? Yes, because that's what Dolly, the the new, automatic wunderkind brought about, in all its innocence, and here's the corresponding fragment from the play (Dolly served as a collateral for a loan to Eliza from the Shark-Blue Bank, but Eliza defaulted on the loan, so the collateral has been delivered to the bank). Triple-X is the helper of the bailiff.

DOLLY

  Well, the honorable bailiffs tried to dump me on the sharks of the Skye-Blue Bank.

TRIPLE-X

  Shark-Blue Bank.

DOLLY

  I thought...let's annoy the bankers beyond repair so that they'll send me back to the doctor. I don't want to work for a bank, you see. I'm a communist at heart...

Why Vladimir Putin would be a fool to go nuclear in Ukraine

By Lewis Page

(This article was recommended by Victor Toth, the top physicist on the top Q&A internet engine. It appeared first here. Michael believes it's worth the reading effort)


Back during the Cold War there was always a question facing the nations of Nato, as they confronted enormous Soviet tank armies in Europe.

In the event of a conventional war going badly, at what point do we go nuclear?

The answer might have been: not until Soviet troops entered France. This kind of problem is why nukes didn't make conventional forces obsolete.

Today it is Vladimir Putin who has a conventional war which is going badly. He still holds large areas of Ukrainian territory, but his troops are falling back.

Putin may be able to mobilise at least some of the huge reserves of manpower which are theoretically available with a full Russian call-up, though this appears to be going extremely badly so far.

Even if a useful mobilisation can be conducted without overwhelming domestic opposition, Russia will struggle to equip its unwilling cannon-fodder and supply them for a long-term war.

The new conscripts will be facing determined Ukrainians who are fighting to save their people from murder, rape, torture and mass disappearance into the gulags. Ukrainian troops have already stopped Russia’s best, the “kontraktniki” professional soldiers who began the invasion, literally dead in their tracks.

Even Russians should be able to see that seizing territory and then going nuclear if it’s taken back is not something the rest of the world can possibly accept.

Worse still, as long as some Western nations remain resolute, the Ukrainians will be well armed and supplied from effectively inexhaustible resources of money and material.

The West in general does not maintain huge stockpiles of munitions and there may well be hiccups in the supply chains. Nonetheless the US in particular has shown during recent wars – for instance in Syria when shortages of surgical smart weapons occurred – that it can crank up new production very quickly when it wants to.

So Putin is under pressure. But he is not in the situation that Nato might have been in a hot 1980s war, reeling back towards France. Putin is not back from his start line, but still well forward of it.

Heads I win, tails I go nuclear

Even Russians should be able to see that seizing territory and then going nuclear if it’s taken back is not something the rest of the world can possibly accept. And bogus gunpoint referendums clearly don't make Ukrainians into Russians.

Russians know this too, as they didn't get a vote on whether they would like to be Russian, or on anything else.

What is this --- Carla, Arfai, MOMA, Robots, TESLA, Dolly

This looks like a famous exhibition piece in the garden of a museum, doesn't it? The Getty Museum in LA, for example, or the MET cloisters in New York City, or the MOMA.

MOMA? Yes, the Museum of Modern Art, also located in New York City. 

Hold on, the MOMA doesn't have a garden. But our house here in Alcobaça, PT has one:

And the hands themselves, then? Well, they are a good-bye present from our neighbor Carla Moreira.

Carla in front of her offices

She sold her house next door and moved to an apartment atop her ceramics factory nearby, where these hands are made. 

One day, the hands will be famous, since Arfai, Carla's company, is a prime maker of high-end ceramics, and you must absolutely have a look at Arfai's web site.

Why, then, do we talk about the MOMA?

Because we wrote a play, a comedy about robots, in which the MOMA plays a role. And yesterday was TESLA's AI-day, which was also about robots, in pacticular about their new inhouse robot Optimus.  

It's practically finished, our play, and here is a fragment:

(Context: Robert was built long ago by Steve as a protoype of his future line of household robots and given to his then-girlfriend Eliza as a parting gift with the promise to return 25 years later with the latest version of said household robots. Today is the day, and the name of this latest version is Dolly. Dolly is urgently needed because Robert--technologically outdated--will no longer supported/updated. Robert knows that he'll soon be redundant, and he has just complained that he'll be ending his existence in a garbage container. One more thing: Dolly is still wrapped up in a garish gift box. Here goes:)

DOLLY (TO ROBERT)

  You're Generation One. You've been discontinued. You're no longer supported.

ROBERT

  I know, I'm on my way out.

DOLLY

  Before you go, please get me out of here.

ROBERT

  Why do you want to get out? Are you afraid in the dark?

DOLLY

  I explained this 10 minutes and 11 seconds ago.

A well-kept secret finally revealed: Albert Einstein turned transsexual later in life

Einstein here with his beloved granddaughter Evelyn

 

IQ-test -- Fill in the blanks

 

Hold the presses

Our friend Glenn sends this:

(If you are puzzled, leave a comment, and we'll explain)

To the triumph of Logic...

So we went to Porto de Mos, the nearby town that dominates the Parque Natural das Serras de Aire e Candeeiros, where we shot our Christmas Card: 

And inside the castle, there was an exposition of contemporary inlay stonework (Porto de Mos prides itself on its stonework). And what do we find? Haven't we founded and run the Applied Logic Laboratory at the University of Amsterdam in our days?

So, we found this:

It's a bit difficult to read, despite some photoshopping, but it says: "To the triumph of logic over the disruption of the truth." A bit optimistic perhaps, this congratulatory shoulder-pat, but now it's set in stone, and we'll hang it on our new walls as soon as we find a printer nearby.

You know this voice ? (2)

You say...

IQ-test

Who said this about whom:

"They are screaming and shouting at people, horribly threatening them..."

(a) Robert S. Mueller about Donald Trump?
(b) Donald Trump about Robert S. Mueller?

Did you know...

Why we like Paul Krugman

Krugman is always good, but here's one of his krugest statements. I've been thinking about it since I read it in the NYT in 2016, long before the elections:

And, yes, this being us, now we have to paddle our wares. There's nothing about Krugman in This Is Heaven, but we have an entire Krugman chapter in the GREEN EYES, Chapter 38, titled (don't hold your breath): "What's Paul Krugman's Penis Size."

Fragment:  

I have been courageous enough to ask for a table for two to be ready at seven, we’ll have to wait some more. Howard will have a drink at the bar. Let’s get this on track immediately, let’s talk about the gym. I didn’t have a chance to go to the gym during the last couple of days, too busy. You can’t imagine how busy life is for a hippocampus teacher during the college break, but tomorrow I’ll be going (duh, duh, duh). So I’m teaching French. How interesting. Interesting, indeed. How to turn the conversation to murder? I seemingly can’t make the transition, bubbling instead about the influence of French on the evolution of English, or hiding the many weaknesses of my résumé.

I see two tables cleared next to the central window on the street side, very good tables indeed, when I notice two people to my left, who have replaced the beefy guy. I’ve seen the face of the man before, on my blog, actually. We’re famous in Georgia Beach, seriously, folks. Will I tell Trevor? You think Trevor would be interested in politics, or the New York Times, or economics, or Nobel prizes? Possibly not—you have other problems when you’re a confirmed bachelor without a future. Trevor, who must be looking right into the eyes of Paul Krugman behind me, shows no signs of recognition what-so-ever. It’s crystal-clear, he’s not attracted to the fifty-nine year old Nobel laureate.

Donald Trump, seriously

(Trump Jump, Twitler, immigrant, kakistocracy, Donald Lump, trumpcare, Trump Treatment, Tyrannosaurus rump, alternative facts, Hot Donald, Trumps Razor, small hands:  The Urban Dictionary, our favorite linguistic cyclopedia, has dropped its habitual preoccupation with matters autoerotic and gone full Trump Dump since the Machtsübernahme, and so our friend Glenn wants to know what we think about the new president. Glenn's particularly interested in answers regarding Trump's intelligence:)

Trump is intelligent, at least technically. He can think on his feet, he's wily, sly, cunning, and has been successful for more than forty years in a difficult business---not as successful as he claims, but he's survived four or six bankruptcies, several trophy wives, and a grueling election campaign---you can't do this without substantial raw intelligence. There are NYT reports regarding his deal making, which emphasize that his negotiation skills really shine when we get into the fine print (the annotations of complex real-estate contracts)---meaning that even his attention span is substantial when he's into a "deal." And then there is corroborating evidence about his work as developer---a developer obsessed with details, we read. So yes, he's clever.

Which doesn't mean he's Socrates. He's not an intellectual, let alone a thinker. He won't take time to think unless it's urgent business. He's a results man---or business man---in the worst conceivable sense. And he's extremely narcissistic---no need to elaborate, just one more anecdote (we quote the Washington Post):

The headless horseman --- This is heaven --- teaser (19)

Alex and John are meeting Godehart in the Blue Moon to commiserate about the German's ouster from the festival contest. One paragraph into this Inspector LaStrada will make his appearance, the homicide detective who is in charge of the investigation of Neill Palmer's death. And the talk about the goldfish bowl? Bit complicated to explain, have a look here.

Godehart is expecting us at a bar table where he had a few shots already. “How did it happen,” we ask. Well, he failed to get the earphone working again. And the confusion. Whether he talked to the mayor. No, the mayor had disappeared. He talked to Beeblebrox though.
“Beeblebrox was very upset, I did better than Roper, he said. I should register a protest.”
“With whom?” Alex asks.
“My guardian angel, I presume.”
And the paper work? Did they at least provide him with a copy of the paperwork? No, nothing. Hamblin is basically incommunicado. And so is the City Club. A bunch of thugs. He learned his lesson, and orders another round.

Sorry to interrupt this.

Sorry to interrupt this, real quick: (a) have you seen the movie Sleepy Hollow with Jonny Depp as inspector Crane and Christopher Walken as the headless horseman (Depp stays a bit too much in character, doesn’t he?)? The horseman is Irish folklore, there are also headless versions without horse; (b) talking hyperboles; (c) you recall inspector LaStrada. He’s entering the premises of the Blue Moon as we speak, and he looks tonight like a horseless, headless inspector who wears a fishbowl under his arm, I swear.

How not to use dope

Make it full screen, stare at it for the duration of the forty seconds it lasts, the look elsewhere. Apparently, the Strobe-illusion tricks your brain to release the drug DMT, in small quantities, and for a minute thereafter you enjoy real hallucinations. The walls undulating, and stuff. Really works. Great. As if we had nothing better to do.

I knew it, I knew it

Be yourself

Can you read this? (2) (Jacki)

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(Yes, we actually mean it, can you read this?)

(Only 55 out of 100 people can!)